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Granulocyte-Colony Stimulating Factor Receptor (G-CSFR)

Granulocyte-Colony Stimulating Factor Receptor (G-CSFR)

Manufacturer	Anogen
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Hematology Leukemia Western Blot Primary Antibodies By Organ Heart & Blood Cancer Bone Cancer Astrocyte Markers
Type	Antibody Monoclonal
Specific against	Human
Clone	S-1374
Isotype	IgG2a kappa
Format	Aff. Pur
Applications	WB
Protein Family	Cytokine, Growth Factors
Amount	0.5mg
Host	Mouse
Item no.	ANOG-MO-C40045E
Targets	CSF3R
eClass 6.1	32160702
eClass 9.0	42030590
Available
Description	Mouse monoclonal antibody to human granulocyte colony stimulating factor receptor (G-CSFR)
Target Protein	Human G-CSFR
Immunogen	Purified recombinant MBP-GCSFR fusion protein
Specificity	Reactive with G-CSFR and does not cross-react with MBP or BSA (bovine serum albumin)
Purification	Protein G affinity purified
Species Reactivity	Human, other species not tested
Myeloma	Sp2/0-Ag14
Background	Granulocyte colony stimulating factor receptor (G-CSFR) exists on the cell surface of the hematopoietic progenitor cell in bone marrow, in mature hematopoietic cells and stromal cells. Binding with granulocyte colony stimulating factor (G-CSF) to the extracellular ligand-binding region of G-CSFR triggers G-CSFR to form homodimer. The conformational changes in G-CSFR activate the cytoplasmic portion of the receptor and trigger signal transduction through Jak Lyn, Stat and erk1/2. The pathway is important for hematopoiesis and was found to be implicated in congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia.
Formulation	Lyophilized from a solution in 0.01M PBS, pH 7.2.
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Application info	Western Blot: The antibody, when used at concentration of 1-10ug/mL will allow visualization of 250ng/lane of human G-CSFR-MBP. The antibody recognizes denatured G-CSFR in Western blot following SDS-PAGE. Suggest use 200?g of cell lysate or immunoprecipitated protein.
Research Area	Cytokine receptor. Hematopoiesis
Storage	Store at -20C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5mg

available

Delivery expected until 7/15/2024