Erythropoietin (EPO)

Mouse monoclonal antibody to human erythropoietin (EPO)

Purified CHO cell-expressed recombinant human EPO

Protein G affinity purified

Does not cross react with other human cytokines tested such as IL-8, IL-16, IL-7, MCP-1, TNF-beta, GM-CSF, M-CSF, IL-1beta, bFGF, and human serum albumin or bovine serum albumin.

Erythropoietin (EPO), also known as hematopoietin is a glycoprotein cytokine that regulates the red blood cell production from the precursor cells in bone marrow. In fetal and perinatal period, EPO is mainly produced by the perisinusoidal cells in liver. In adults, majority of EPO is produced in the interstitial fibroblasts in kidney. EPO is necessary for red blood cell production, also stimulates angiogenesis and proliferation of smooth muscle cells. Recombinant EPO (rEPO) has been applied for treatment of anaemia. And the investigation into its neuronal protection effect in hypoxic conditions (stroke, myocardial infarction etc.) is ongoing. Some individuals use rEPO to enhance performance in sports.

Double distillated water is recommended to reconstitute the antibody.

Hematology