Macrophage/Monocyte Chemotactic Protein (MCP-3)

Mouse monoclonal antibody to human macrophage/monocyte chemotactic protein-3 (MCP-3)

Recombinant human MCP-3 (M.W. 8.5kDa containing 76 amino acids residues)

Protein G affinity purified

Does not show any cross reaction with other human cytokines or growth factors tested such as IL-1beta, IL-8, MCAF, SAA and EGF.

Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1alpha to bind to CCR1.
MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.

Double distillated water is recommended to reconstitute the antibody.

Cytokine, chemotaxis.