Protein C

Mouse monoclonal antibody to human protein C

Purified human Protein C derived from human blood

Human, others not tested

Protein C is a vitamin K dependant glycoprotein in blood. Activated Protein C (APC) functions as an anti-coagulation factor in blood by proteolyzing pro-coagulation factors including Factor V and Factor VIII. When bound with endothelial protein C receptor (EPCR) on vascular endothelial cells, APC acts on protease activated receptor I (PAR-1) to up-regulate the expression of genes involved with anti-inflammatory and anti- apoptotic pathways, thus it also possesses a cell protective function. Protein C is activated by binding with thrombin. The activation is enhanced by thrombomodulin and EPCR.

Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.

Hematology, anti-coagulation