Protein Tyrosine Phosphotase (PTP1C)

Human protein-tyrosine phosphatase 1 C

This antibody recognizes single 67kDa PTP1-C in human cells that express the enzyme and the SH2(C) domain.

Human

The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocyte-specific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.

Double distilled water is recommended to adjust the final concentration to 1.00 mg/ml.

Signal transduction