Beta amyloid peptide 42

Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)

KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42

Protein G affinity purified

The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA.

Amyloid beta peptide 42 (Abeta42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer’s disease. Abeta42 and Abeta40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Abeta42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Abeta42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Abeta42 contributes to the pathogenesis of Alzheimer’s disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer’s disease. Another is that the neurotoxicity of Abeta42 oligomer is the cause of the disease.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Aging and neurodegenerative diseases