Alpha-Synuclein

Human alpha-synuclein

This antibody recognizes the recombinant alpha-synuclein.

Human

alpha-synuclein is a protein of unknown function. It is mainly found in neural tissue. There is a lipid-binding motif similar to that of Apolipoproteins on its N-terminal. A hydrophobic region that is the non-beta component found in amyloid aggregation in Alzheimer’s disease is located at the central region of the protein. The abnormal aggregation of alpha-synuclein on brain tissue is called Lewy bodies, which are found in Parkinson’s disease, dementia and multiply system atrophy. Mutated alpha-synuclein gene is found to be associated with rare familial form of Parkinson’s disease.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Parkinson’s disease, neurodegenerative diseases.