Formyl Peptide Receptor-like 1 C-terminal (FPRL-1)

Mouse monoclonal antibody against C-terminal amino acid sequence on human formyl peptide receptor-like 1(FPRL1)

A short peptide corresponding to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 was conjugated with KLH for immunization.

Protein G affinity purified

Not identified

Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-alpha by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

G-protein coupled membrane receptor, chemotaxis and Alzheimer’s disease.