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mAb anti-human promyelocytic leukemia protein (PML)

mAb anti-human promyelocytic leukemia protein (PML)

Item no.	ANOG-MO-T40010B-0.1mg
Manufacturer	Anogen
Amount	0.1mg
Category	Oncology Antibodies By Cell Type Hematology Leukemia Western Blot Primary Antibodies By Organ Heart & Blood Cancer Testicular & Prostate Cancer
Type	Antibody Monoclonal
Applications	WB
Clone	B4C8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Available
Description	Mouse monoclonal antibody to human promyelocytic leukemia protein (PML) ring finger domain
Target Protein	Human PML and PML/RARalpha chimera
Immunogen	Recombinant partial human PML containing the ring finger domain
Specificity	This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARalpha chimeric protein in promyelocytic leukemia patients.
Purification	Protein G affinity purified
Myeloma	Sp2/0-Ag14
Light chain	Kappa
Background	Acute promyelocytic leukemia (PML) is a type of acute myelogenous leukemia that is caused by the translocation of the retinoic acid receptor alpha (RARalpha) gene at chromosome 17 to the promyelocytic leukemia (PML) gene at chromosome 15. The chimeric protein (PML/RARalpha) has a higher molecular weight than normal PML protein. The altered proteins block DNA transcription and differentiation of granulocytes, reduce the production of red cells and platelets, consequently, resulting in anemia and thrombocytopenia.
Formulation	Lyophilized in pH 7.4, 0.01M PBS.
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area	Tumor Research
Storage	Store at -20oC

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1mg

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Delivery expected until 12/18/2025

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