Anti-IL-1 Beta Antibody

IL-1 beta

Rabbit polyclonal antibody to IL-1 beta.

Recombinant Chicken IL-1 beta.

Supplied in Phosphate Buffered Saline.

This antibody recognises chicken Interleukin 1 beta (chIL-1beta), which shares homology with mammalian IL-1beta.IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression.Chicken models indicate physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.Rabbit anti Chicken interleukin-1 beta antibody (AHP941Z) neutralizes chicken IL-1 beta.