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AML1 Antibody (Ab-435)

AML1 Antibody (Ab-435)

Item no.	AP50013
Manufacturer	Abcepta
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RUNX1, AML1, CBFA2, Acute myeloid leukemia 1 protein, Runt-related transcription factor 1, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit
Available
Primary Accession	Q01196
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation.
Bio References	Ahn M.-Y., et al.Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases. Miyoshi H., et al.Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991). Sacchi N., et al.Genes Chromosomes Cancer 11:226-236(1994). Nucifora G., et al.Blood 81:2728-2734(1993). Levanon D., et al.Genomics 23:425-432(1994).
Clonality	Polyclonal
Gene ID	861
Gene Name	RUNX1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of lysate from SW620 cell line, using AML1 Antibody (Ab-435) (B8287). B8287 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
Type image 1	WB
Dilution image 1	1:1000

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/4/2025

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