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Smad2 Antibody (Ab-465)

Smad2 Antibody (Ab-465)

Item no.	AP50015
Manufacturer	Abcepta
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Smad2, SMAD2, Mothers against DPP homolog 2, SMAD 2, JV18-1, MADH2, hSMAD2, hMAD-2, MADR2, Mothers against decapentaplegic homolog 2, MAD homolog 2, Mad-related protein 2, SMAD family member 2
Available
Primary Accession	Q15796
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Bio References	Riggins G.J., et al.Nat. Genet. 13:347-349(1996). Zhang Y., et al.Nature 383:168-172(1996). Eppert K., et al.Cell 86:543-552(1996). Liu F., et al.Genes Dev. 11:3157-3167(1997). Takenoshita S., et al.Genomics 48:1-11(1998).
Clonality	Polyclonal
Gene ID	4087
Gene Name	SMAD2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of lysates from HepG2, NIH/3T3 cell line (from left to right), using Smad2 Antibody (Ab-465)(B9058). B9058 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
Type image 1	WB
Dilution image 1	1:1000

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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