Comparison

Anti-TACR1

Item no. ARP-10-P1684
Manufacturer American Research Products
Amount 100 ug
Category
Type Antibody Polyclonal
Specific against other
Citations 1. Castagliuolo, I., Riegler, M., Pasha, A., Nikulasson, S., Lu, B., Gerard, C., Gerard, N. P., Pothoulakis, C.Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis.J. Clin. Invest. 101: 1547-1550, 1998. 2. George, D. T., Gilman, J., Hersh, J., Thorsell, A., Herion, D., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R., Brandt, J. E., Gehlert, D. R., Tauscher, J. T., Hunt, S. P., Hommer, D., Heilig, M.Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.Science 319: 1536-1539, 2008.3.Lai, J.-P., Ho, W. Z., Kilpatrick, L. E., Wang, X., Tuluc, F., Korchak, H. M., Douglas, S. D.Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.Proc. Nat. Acad. Sci. 103: 7771-7776, 2006.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias NK-1 receptor
Available
Description
Rabbit IgG polyclonal antibody for Substance-P receptor (TACR1) detection. Tested with WB in Human, Mouse, Rat.
Background
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human TACR1, identical to the related rat and mouse sequences.
Form
Lyophilized
Specificity
Human, Mouse, Rat. No cross reactivity with other proteins.
Storage
2-8C. For long term -20C after reconstitution.
Synonyms
NK-1 receptor
References
  • 1. Castagliuolo, I., Riegler, M., Pasha, A., Nikulasson, S., Lu, B., Gerard, C., Gerard, N. P., Pothoulakis, C.Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis.J. Clin. Invest. 101: 1547-1550, 1998.
  • 2. George, D. T., Gilman, J., Hersh, J., Thorsell, A., Herion, D., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R., Brandt, J. E., Gehlert, D. R., Tauscher, J. T., Hunt, S. P., Hommer, D., Heilig, M.Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.Science 319: 1536-1539, 2008.
  • 3.Lai, J.-P., Ho, W. Z., Kilpatrick, L. E., Wang, X., Tuluc, F., Korchak, H. M., Douglas, S. D.Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.Proc. Nat. Acad. Sci. 103: 7771-7776, 2006.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Purification
Immunogen affinity purified.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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