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Anti-Promyelocytic leukemia protein (PML)

Anti-Promyelocytic leukemia protein (PML)

Item no.	ARP-29-T40010B
Manufacturer	American Research Products
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	B4C8
Specific against	other
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Available
Description	Mouse monoclonal antibody to human promyelocytic leukemia protein (PML) ring finger domain
Background	Acute promyelocytic leukemia (PML) is a type of acute myelogenous leukemia that is caused by the translocation of the retinoic acid receptor alpha (RARa) gene at chromosome 17 to the promyelocytic leukemia (PML) gene at chromosome 15. The chimeric protein (PML/RARa) has a higher molecular weight than normal PML protein. The altered proteins block DNA transcription and differentiation of granulocytes, reduce the production of red cells and platelets, consequently, resulting in anemia and thrombocytopenia.
Immunogen	Recombinant partial human PML containing the ring finger domain
Form	Purified, in 0.01M PBS, pH 7.4
Specificity	This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARa chimeric protein in promyelocytic leukemia patients.
Storage	Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Concentration	1 mg/ml
Interest Field	Life science research, Oncology
Antigen Recognized in Species	Human, others not tested

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/18/2025

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