Anti-E-Cadherin

Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene. E-cadherin is a Ca(2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. It has 16 exons spanning approximately 100 kb of genomic DNA. The gene structure is similar to that of other cadherins. E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression.

Purified, in TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Store at 2-8C (Short Term). Aliquot and store at -20C for long term. Avoid repeated freeze and thaw cycles.

999