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Anti-AKAP12 Antibody PicobandÂ®

Anti-AKAP12 Antibody PicobandÂ®

Item no.	BOS-A02303-3
Manufacturer	Boster
Amount	100 ug/vial
Category	Antibodies Primary Antibodies
Type	Antibody
Format	Lyophilized
Applications	WB, FC, IF, IHC, ICC, ELISA
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Gordon, T., Grove, B., Loftus, J. C., O'Toole, T., McMillan, R., Lindstrom, J., Ginsberg, M. H. Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. J. Clin. Invest. 90: 992-999, 1992. 2. Lee, S.-W., Kim, W. J., Choi, Y. K., Song, H. S., Son, M. J., Gelman, I. H., Kim, Y.-J., Kim, K.-W. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nature Med. 9: 900-906, 2003. 3. Nauert, J. B., Klauck, T. M., Langeberg, L. K., Scott, J. D. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr. Biol. 7: 52-62, 1997.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Tumor necrosis factor receptor superfamily member 14;Herpes virus entry mediator A;Herpesvirus entry mediator A;HveA;Tumor necrosis factor receptor-like 2;TR2;CD270;TNFRSF14;HVEA, HVEM;UNQ329/PRO509;
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	300 kDa
Calculated Molecular weight	30392 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.25?g/ml, Mouse Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Mouse Immunocytochemistry/Immunofluorescence, 5?g/ml, Mouse Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells, Mouse, Rat ELISA, 0.1-0.5?g/ml, -
Manufacturer - Gene Name	Akap12
Gene Full Name	Tumor necrosis factor receptor superfamily member 14
Background	A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Immunogen	E.coli-derived mouse AKAP12 recombinant protein (Position: E387-H1620).
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Antiviral Signaling, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Innate Immunity, Signal Transduction, TNF Superfamily
Protein Name	Tumor necrosis factor receptor superfamily member 14
Protein Function	Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Subcellular Localization	Membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-AKAP12 Antibody Picoband® catalog # A02303-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Widely expressed, with the highest expression in lung, spleen and thymus.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A02303-3-datasheet.pdf

BOS-A02303-3-safety-datasheet.pdf