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Anti TAR DNA-Binding Protein 43 (TDP-43), phospho-Ser409/410 mAb (Clone 11-9) (in PBS)

Anti TAR DNA-Binding Protein 43 (TDP-43), phospho-Ser409/410 mAb (Clone 11-9) (in PBS)

Item no.

CAC-TIP-PTD-M01A

Manufacturer

Cosmobio

Amount

100 ul

Category

Type

Antibody Monoclonal

Format

Liquid

Applications

WB, IHC, ELISA

Clone

11-9

Specific against

Human (Homo sapiens)

Host

Mouse

Source

culture supernatant

Isotype

IgG1

Conjugate/Tag

unlabeled

ECLASS 10.1

42030590

ECLASS 11.0

42030590

UNSPSC

12352203

Available

Manufacturer - Applications

ELISA, IHC(f), WB

Manufacturer - Category

Antibodies/Neurodegeneration/Primary Antibodies; Antibodies/Primary Antibodies/Neurodegeneration; Research Area/Cell Biology/Apoptosis/Primary Antibodies; Research Area/Cell Biology/Cell Cycle/Primary Antibodies; Research Area/Cell Biology/Cell Survival/Primary Antibodies; Research Area/Cell Biology/Gene Expression & Transcription/Primary Antibodies; Research Area/Cell Biology/Nuclear Import & Export/Primary Antibodies; Research Area/Cell Biology/Post Translational Modification & Processing/Primary Antibodies; Research Area/Cell Biology/Protein stability/Primary Antibodies; Research Area/Cell Biology/RNA biogenesis/Primary Antibodies; Research Area/Cell Biology/RNA Processing/Primary Antibodies; Research Area/Cell Biology/RNA Splicing/Primary Antibodies; Research Area/Cell Biology/RNA stability/Primary Antibodies; Research Area/Cell Biology/Viral transcription/Primary Antibodies; Research Area/Cell Types/Neurons/Primary Antibodies; Research Area/Development/Muscle/Primary Antibodies; Research Area/Disease/Alzheimer's Disease/Primary Antibodies; Research Area/Disease/Amyotrophic Lateral Sclerosis/Primary Antibodies; Research Area/Disease/Frontotemporal Dementia/Primary Antibodies; Research Area/Immunology & Inflammation/Virus/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Mitochondria/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Stress Granules/Primary Antibodies; Research Area/Systemic Physiology/Circadian Clock/Primary Antibodies

Maker

CAC

Short Description

Replacement for Cat No.: CAC-TIP-PTD-M01

Description

Anti-TAR DNA-Binding Protein 43 (TDP-43), phospho-Ser409/410 mAb 11-9 was cloned from mice immunized with diphospho-peptide [CMDSKS(p)S(p)GWGM]. 11-9 recognizes human TDP-43 phosphorylated on serines 409 and 410. 11-9 is validated for western blot, ELISA and IHC(f). This antibody is a powerful tool for biochemical and immunohistochemical analyses of TDP-43 proteinopathy.

TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.

This antibody is a powerful tool for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Cat. No. CAC-TIP-PDT-M01A Product Specifications

Product type
Purification	affinity purified
Clonality	Monoclonal
Immunogen	CMDSKS(p)S(p)GWGM, S(p): phosphoserine 409/410
Manufacturer - Specificity	phospho-TDP-43
Note:	Important Notice About Format Change: For lots "11-9-20" and newer, this antibody is now provided as ammonium sulfate precipitated culture supernate, formulated in 50% glycerol, 0.05% NaN3. Older lots were provided as raw culture supernate. Vials of the previous format remain available while supplies last. (posted: March 2020). This has improved sensitivity, and does not require altering current protocols.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CAC-TIP-PTD-M01A-datasheet.pdf

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Amount: 100 ul

available

Delivery expected until 9/11/2025

Express Delivery: Save 3 days

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