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anti- ARHGEF18 antibody

anti- ARHGEF18 antibody

Manufacturer	FineTest
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Specific against	Human, Mouse
Isotype	IgG
Format	liquid
Amount	100ug
Host	Rabbit
Item no.	FNab00561-100ug
eClass 6.1	32160702
eClass 9.0	42030590
Available
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Clonality	polyclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
Immunogen	rho/rac guanine nucleotide exchange factor(GEF) 18
Observed MW	120-130 kDa
Uniprot ID	Q6ZSZ5
Tested Application	ELISA, WB, IHC
Recommended dilution	WB: 1:500-1:2000; IHC: 1:20-1:200
Gene ID	23370
Research Area	Signal Transduction, Metabolism

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 6/27/2024