Item no. |
FNab00860-100ug |
Manufacturer |
FineTest
|
Amount |
100ug |
Category |
|
Type |
Antibody Monoclonal |
Format |
liquid |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
ATG6, Beclin 1, beclin 1, autophagy related, beclin1, BECN1, GT197, Protein GT197, VPS30 |
Available |
|
Purification |
Immunogen affinity purified |
Purity |
>=95% as determined by SDS-PAGE |
Clonality |
polyclonal |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.) |
Background |
Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy. |
Immunogen |
beclin 1, autophagy related |
Observed MW |
60 kDa |
Uniprot ID |
Q14457 |
Tested Application |
ELISA, IHC, WB, IF |
Recommended dilution |
WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200 |
Gene ID |
8678 |
Research Area |
Cancer, Immunology, Metabolism |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.