Item no. |
FNab00932-100ug |
Manufacturer |
FineTest
|
Amount |
100ug |
Category |
|
Type |
Antibody Monoclonal |
Format |
liquid |
Clone |
2B10 |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus) |
Host |
Mouse |
Isotype |
IgG1 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
BORIS, Cancer/testis antigen 27, CCCTC binding factor, CT27, CTCF like protein, CTCF paralog, CTCF T, CTCFL, dJ579F20.2, Zinc finger protein CTCF T |
Available |
|
Purification |
Protein A+G purification |
Purity |
>=95% as determined by SDS-PAGE |
Clonality |
monoclonal |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.) |
Background |
CTCFL, also named BORIS(for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region(ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. |
Immunogen |
CCCTC-binding factor(zinc finger protein)-like |
Observed MW |
75 kDa |
Uniprot ID |
Q8NI51 |
Tested Application |
ELISA, WB, IF |
Recommended dilution |
WB: 1:500-1:2000; IF: 1:10-1:100 |
Research Area |
Metabolism |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.