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CACNA1S antibody

CACNA1S antibody

Item no.	FNab01173-100ug
Manufacturer	FineTest
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Voltage-dependent L-type calcium channel subunit alpha-1S,Calcium channel,L type,alpha-1 polypeptide,isoform 3,skeletal muscle,Voltage-gated calcium channel subunit alpha Cav1.1,CACNA1S,CACH1,CACN1,CACNL1A3
Available
Manufacturer - Targets	CACNA1S
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Clonality	polyclonal
Immunogen	calcium channel, voltage-dependent, L type, alpha 1S subunit
Observed MW	200-220 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000; IHC: 1:20-1:200
Manufacturer - Research Area	Neuroscience

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