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CALCOCO2 antibody

CALCOCO2 antibody

Item no.	FNab01196-100ug
Manufacturer	FineTest
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Calcium-binding and coiled-coil domain-containing protein 2,Antigen nuclear dot 52 kDa protein,Nuclear domain 10 protein NDP52 (Nuclear domain 10 protein 52),Nuclear dot protein 52,CALCOCO2,NDP52
Available
Manufacturer - Targets	CALCOCO2
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy(PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation(PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C(PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion(PubMed:17635994).
Clonality	polyclonal
Immunogen	calcium binding and coiled-coil domain 2
Observed MW	52 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200
Manufacturer - Research Area	Signal Transduction, Metabolism

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