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SMARCD3 antibody

SMARCD3 antibody

Item no.	FNab08013-100ug
Manufacturer	FineTest
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3,60 kDa BRG-1/Brm-associated factor subunit C,BRG1-associated factor 60C (BAF60C),SMARCD3,BAF60C
Available
Manufacturer - Targets	SMARCD3
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity).
Clonality	polyclonal
Immunogen	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Observed MW	54 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000; IF: 1:20-1:200
Manufacturer - Research Area	Cardiovascular, Metabolism

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