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Anti-Rat ALK-7 - Biotin - 50 µg

Anti-Rat ALK-7 - Biotin - 50 µg

Item no.	LEIN-A400-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Western Blot Primary Antibodies Astrocytoma
Type	Antibody Primary
Applications	WB
Specific against	Rat (Rattus norvegicus)
Host	Caprine
Citations	1. Kim, SJ. et al. (2004) J Biol Chem. 279: 28458 2. Ritvos, O. et al. (2001) Cytogenet Cell Genet. 95: 157 3. Ibanez, CF. et al. (2008) Proc Natl Acad Sci USA 105: 7246 4. Ibanez, CF. et al. (2008) Health & Medicine
NCBI	245921
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: To detect Rat ALK-7 this biotin conjugate can be used at a concentration of 0.1 - 0.2 µg/ml. This biotin conjugate should be used in conjunction with compatible second-step reagents such as PN:A106 and a chromogenic substrate such as PN:T343. The detection limit for Rat ALK-7 is 25 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:A345.
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	ALK-7
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Activin receptor-like kinase (ALK) 7 is a type I serine/threonine kinase receptor of the transforming growth factor (TGF)-beta family of proteins.1 ALK7 is most abundantly expressed in human brain, pancreas and colon.2 It negatively regulates glucose-stimulated insulin release in β-cells3 and plays an important role in regulating the functional plasticity of pancreatic islets.4 ALK7 also has an important role in the regulation of body fat deposition. These has implications for the development of treatments against diabetes and obesity.5
Background	Activin receptor-like kinase (ALK) 7 is a type I serine/threonine kinase receptor of the transforming growth factor (TGF)-beta family of proteins.¹ ALK7 is most abundantly expressed in human brain, pancreas and colon.² It negatively regulates glucose-stimulated insulin release in β-cells³ and plays an important role in regulating the functional plasticity of pancreatic islets.⁴ ALK7 also has an important role in the regulation of body fat deposition. These has implications for the development of treatments against diabetes and obesity.⁵
PubMed	ALK-7
Manufacturer - Specificity	Goat Anti-Rat Activin Receptor-Like Kinase 7 (ALK-7) recognizes Rat ALK-7. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2828148
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Rat ALK-7 (Accession # NP_620790)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Activin Receptor-Like Kinase 7, ALK-7, Rat, Anti-Rat ALK-7-Biotin, Rat ALK 7, activin A receptor, type IC, Activin receptor type IC, activin receptor type-1C, Activin receptor-like kinase 7, Activin RIC, ACTR-IC, ACVR1C, ACVRLK7, ALK7, ALK-7, ALK7ALK-7, EC 2.7.11, EC 2.7.11.30

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-A400-50ug-safety-datasheet.pdf