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Anti-Mouse CD137 (4-1BB) - Biotin - 50 µg

Anti-Mouse CD137 (4-1BB) - Biotin - 50 µg

Item no.	LEIN-B561-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Flow Cytometry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, FC, ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	Caprine
Citations	1. Shan, B. et al. (2008) Cell Mol Immunol. 5: 379 2. Kwan, BS. et al. (2009) J Immunol. 182: 4107 3. Kwan, BS. et al. (1998) Eur J Immunol. 28: 881 4. Kwan, BS. et al. (1996) Cell Immunol. 169: 91
NCBI	21942
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Det, FC, WB
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines\|Primary Monoclonal Antibodies>Immune Checkpoints
Manufacturer - Targets	4-1BB
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.
Background	4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.
PubMed	4-1BB
Manufacturer - Specificity	Goat Anti-Mouse 4-1BB recognizes Mouse 4-1BB. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2828233
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Antigen Distribution	4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells.
Immunogen	Purified Recombinant Mouse 4-1BB (> 98%) (Accession # P20334)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, 4-1BB, TNFRSF9, CD137 Antigen, T-Cell Antigen ILA, Mouse, Anti-Mouse 4-1BB-Biotin, 4-1BB ligand receptor, 41BB, 4-1BB, CD137 antigen, CD137, CD137MGC2172, CDw137, FLJ43501, ILA, ILAhomolog of mouse 4-1BB, induced by lymphocyte activation (ILA), interleukin-activated receptor, homolog of mouse Ly63, receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, tumor necrosis factor receptor superfamily member 9, tumor necrosis factor receptor superfamily, member 9, 41bb, anti 4-1bb, anti-4-1bb, anti 41bb

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-B561-50ug-safety-datasheet.pdf