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Anti-Mouse CD86 - Purified - 500 µg

Anti-Mouse CD86 - Purified - 500 µg

Item no.	LEIN-C2050-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Category	Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies
Type	Antibody Monoclonal
Applications	FC, IP
Clone	GL1
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
NCBI	12524
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Immune Checkpoints\|Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	B7-2
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
Background	CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
PubMed	B7-2
Ligand/Receptor	CD28, CD152 (CTLA-4)
Manufacturer - Research Area	Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Manufacturer - Specificity	Clone GL-1 recognizes an epitope on mouse CD86.
RRID	AB_2829127
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes.
Immunogen	LPS activated DBA/2J mouse B cells.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	B7-2, CD86, 37301, Human, Anti-Human B7-2, Activation B7-2 antigen, B70, B7-2 antigen, B72, B7-2, B-lymphocyte activation antigen B7-2, BU63, CD86 antigen, CD86 molecule, CD86, FUN-1, LAB72, MGC34413, T-lymphocyte activation antigen CD86, anti b72, anti b7-2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C2050-500ug-safety-datasheet.pdf