Anti-Mouse CD155 - DyLight® 488

Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers

USA

CD155 is a transmembrane glycoprotein member of a subfamily of immunoglobulin-like adhesion receptors (nectins). CD155 is commonly known as Poliovirus Receptor (PVR) because of its involvement as a cellular receptor for poliovirus. The normal function of CD155 is to establish intercellular adherens junctions between epithelial cells. Of its 3 extracellular immunoglobulin-like domains (D1, D2, and D3), the virus only recognizes D1. CD155 interacts with both CD226 and CD96 to induce cytotoxicity of NK cells and CTL. The precise role of CD155 in the immune system remains to be elucidated, though it is suspected to be involved in intestinal humoral immune responses. Furthermore, it is thought that CD155 may be used to positively select MHC-independent T cells in the thymus.

CD155

CD226 (DNAM-1), CD96

Clone 4.24.1 recognizes an epitope on mouse CD155.

0.2 mg/ml

CD155 is expressed at cell junctions on the primary vascular endothelial cells and is highly expressed on DP thymocytes.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.