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Anti-Human Desmoglein-2-Biotin - 50 µg

Anti-Human Desmoglein-2-Biotin - 50 µg

Item no.	LEIN-D345-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Primary
Applications	WB, ICC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Ozcelik, C. et al.(2008) Mol Genet Metab. 95(1-2):74-80.
NCBI	1829
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: To detect Human DSG2 this biotin conjugate can be used at a concentration of 0.1 - 0.2 µg/ml. This biotin conjugate should be used in conjunction with compatible second-step reagents such as PN:A106 and a chromogenic substrate such as PN:T343. The detection limit for Human DSG2 is 0.5 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:D340.
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	Desmoglein-2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted bioin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. It provides cellular adhesion and forces transduction by cell-to-cell anchorage. 1 It also plays a role in embryonic stem cell proliferation.
Background	Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. It provides cellular adhesion and forces transduction by cell-to-cell anchorage. ¹ It also plays a role in embryonic stem cell proliferation.
Other Applications Reported In Literature	Immunocytochemistry: Suitable for use at concentration of 5-15 µg/mL.
PubMed	Desmoglein-2
Manufacturer - Specificity	Goat Anti-Human Desmoglein-2 (DSG2) recognizes Human DSG2. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2829925
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human DSG2 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Desmoglein-2, ARVC10, ARVD10, CDHF5, HDGC, MGC117034, MGC117036, MGC117037, DSG2, Human, Anti-Human Desmoglein-2-Biotin, ARVC10, ARVD10, Cadherin family member 5, CDHF5, CDHF5MGC117034, CMD1BB, desmoglein 2, Desmoglein2, Desmoglein-2, DSG2, HDGC, MGC117036, MGC117037

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-D345-50ug-safety-datasheet.pdf