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Anti-Mouse IL-4 (Clone 11B11) - Purified - 500 µg

Anti-Mouse IL-4 (Clone 11B11) - Purified - 500 µg

Item no.	LEIN-I-1043-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Category	Antibodies Immunohistochemistry Immunoprecipitation ELISA Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Monoclonal
Applications	IP, IHC, ICC, ELISA
Clone	11B11
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Yoshimoto T & Paul WE. (1994) J Exp Med. 179(4):1285–95 2. Kipnis J., at al. (2012) J Immunol. 189(9):4213-4219 3. Groth B., et al. (1992) J Exp Med. 176:1091–8 4. Murphy KM., et al. (1992) Proc Natl Acad Sci USA. 89:6065–9 5. Paul WE., et al. (1999) Annual Rev Immunol. 17:701-38 6. Maquart FX., et al. (2000) Lab Invest. 80(8):1337-43 7. Godeau, G., et al. (2000) Lab Invest. 80,1337–1343 8. Steinke JW & Borish L. (2001) Respir Res. 2(2):66-70
NCBI	16189
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	ELISA Cap, ICC, IHC, IP
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IL-4
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1, 2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3, 4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6, 7 and airway inflammation in patients with asthma8.
Background	IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils^{1, 2}. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells^{3, 4} and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes⁵. In addition, IL-4 is implicated in normal wound healing^{6, 7} and airway inflammation in patients with asthma⁸.
Other Applications Reported In Literature	ICC IHC IP
PubMed	IL-4
Manufacturer - Research Area	Immunology, Other Molecules
Manufacturer - Specificity	Clone 11B11 recognizes an epitope on mouse IL-4.
RRID	AB_2830374
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
Immunogen	Partially Purified Native Mouse IL-4
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin-4, BCGF, BCDF, B Cell Stimulating Factor, BSF-1, 11B11, IL-4, Mouse, Anti-Mouse IL-4 - Purified, HCGF, MCGF-2, MFF, TCGF-2, lymphoid cell growth factor, lymphoid, mast, basophils, T helper subset development, ELISA, ELISPOT, Flow Cytometry, IHC, IP, Neutralization

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-1043-500ug-safety-datasheet.pdf