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Anti-Rat Jagged-1 - Biotin - 50 µg

Anti-Rat Jagged-1 - Biotin - 50 µg

Item no.	LEIN-J110-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, ELISA
Specific against	Rat (Rattus norvegicus)
Host	Caprine
Citations	1. Spinner, NB. et al. (2001) Semin Liver Dis. 21: 525 2. Bhatia, M. et al. (2000) J Exp Med. 192: 1365 3. Chandrasekharappa, SC. et al. (1997) Genomics 43: 376 4. DeVirgilis, S. et al. (1999) Hum Mutat. 14: 394
NCBI	29146
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Det, WB
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	Jagged-1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Jagged 1 (JAG1) is a cell surface protein that functions in an embryologically important signaling pathway, known as the Notch signaling pathway, which is a highly conserved cell signaling system.1 JAG1 plays an essential role in tissue formation during embryonic development of primitive organisms.2 JAG1 is a strong candidate gene for Alagille syndrome (AGS)3 which is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region.4
Background	Jagged 1 (JAG1) is a cell surface protein that functions in an embryologically important signaling pathway, known as the Notch signaling pathway, which is a highly conserved cell signaling system.¹ JAG1 plays an essential role in tissue formation during embryonic development of primitive organisms.² JAG1 is a strong candidate gene for Alagille syndrome (AGS)³ which is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region.⁴
PubMed	Jagged-1
Manufacturer - Specificity	Goat Anti-Rat Jagged 1 recognizes Rat Jagged 1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831068
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	NS0-Derived Recombinant Rat Jagged 1 Extracelluar Domain (Accession # Q63722)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Jagged-1, AGS, AHD, AWS, Cluster of Differentiation (CD339), HJ1, JAGL1, MGC104644, Rat, Anti-Rat Jagged-1-Biotin, Rat Jagged 1, Jagged 1, AGS, AHDMGC104644, Alagille syndrome, AWS, CD339 antigen, CD339, HJ1, JAG1, Jagged 1, Jagged1, JAGL1, protein jagged-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-J110-50ug-safety-datasheet.pdf