« Back
Home /
Anti-Human Lymphotoxin βR - Biotin - 50 µg

Anti-Human Lymphotoxin βR - Biotin - 50 µg

Item no.	LEIN-L232-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Flow Cytometry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, FC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Isine Bolstad, A. et al. (2009) Arthritis Research & Therapy 11: R24
NCBI	4055
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Flow Cytometry: It is recommended to use the indirect method for signal enhancement when enumerating cells expressing Lymphotoxin βR. A suggested method would be to stain cells expressing Lymphotoxin βR with 2.5 µg per 1 x 10⁶ cells in a total staining volume of 100 µl followed by PN:A104. Western Blotting: To detect Human Lymphotoxin βR this biotin conjugate can be used at a concentration of 0.1 - 0.2 µg/ml. This biotin conjugate should be used in conjunction with compatible second-step reagents such as PN:A106 and a chromogenic substrate such as PN:T343. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:L201.
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	Lymphotoxin βR
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Lymphotoxin beta receptor (LTBR), a receptor for lymphotoxin, is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. LTBR pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proved beneficial in autoimmune diseases such as diabetes and rheumatoid arthritis.1
Background	Lymphotoxin beta receptor (LTBR), a receptor for lymphotoxin, is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. LTBR pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proved beneficial in autoimmune diseases such as diabetes and rheumatoid arthritis.¹
PubMed	Lymphotoxin βR
Manufacturer - Specificity	Goat Anti-Human Lymphotoxin Beta Receptor (Lymphotoxin βR) recognizes Human Lymphotoxin βR. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831162
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human Lymphotoxin βR (Accession # P36941)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Lymphotoxin Beta Receptor, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRSF3, L βR, Human Lymphotoxin βR, Anti-Human Lymphotoxin βR-Biotin, CD18, D12S370, ltbetar, LT-BETA-R, LTBR, lymphotoxin B receptor, Lymphotoxin beta R, lymphotoxin beta receptor (TNFR superfamily, member 3), Lymphotoxin-beta receptor, LymphotoxinbR, TNF RIII, TNF Rrp, TNFCRTNF-RIII, TNFR superfamily, member 3, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3, TNFRSF3TNFR-III, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, tumor necrosis factor receptor superfamily member 3, tumor necrosis factor receptor superfamily, member 3, Tumor necrosis factor receptor type III

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

LEIN-L232-50ug-safety-datasheet.pdf