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Anti-Mouse Ly-6G [Clone 1A8] — Purified (PhenoCyler-Fusion (CODEX)® Ready) - 50 µg

Anti-Mouse Ly-6G [Clone 1A8] — Purified (PhenoCyler-Fusion (CODEX)® Ready) - 50 µg

Item no.	LEIN-L500-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Immunohistochemistry Primary Antibodies
Type	Antibody Monoclonal
Applications	IHC
Clone	1A8
Specific against	other
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	IHC FF, PhenoCycler®
Manufacturer - Category	PhenoCycler®>PhenoCycler® Validated Antibodies\|Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	Ly-6G
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Ly6G antibody, clone 1A8, recognizes lymphocyte antigen 6 complex locus G6D (Ly6G; also called Gr-1), a 21-25 kDa glycosylphosphatidylinositol (GPI)-anchored protein1. Ly6G belongs to the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily, characterized by a Ly6/uPAR (LU) domain-containing a three-fingered structural motif stabilized by disulfide bonds2. Ly6G is expressed by murine neutrophils regardless of location and activation1, 4, 5. Eosinophils may also express low levels of Ly6G5. There is no human ortholog for Ly6G; however, a structurally related L76/uPAR protein, CD177 (also known as HNA-2a, NB1, or PRV-1) is expressed in human neutrophils and is implicated in neutropenia6. Although the exact function and ligand of Ly6G remain unknown, Ly6G ligation may impair neutrophil migration to sites of inflammation via a β2-integrin-dependent mechanism7.
Manufacturer - Research Area	Immunology, Inhibitory Molecules, Innate Immunity
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4.
Antigen Distribution	Ly6G is expressed by neutrophils.
Keywords	Monoclonal Antibody, Ly-6G, Lymphocyte Antigen 6 Complex, 1A8, Mouse

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-L500-50ug-safety-datasheet.pdf