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Anti-Human CD52 (Alemtuzumab) - Dylight® 488 - 100 µg

Anti-Human CD52 (Alemtuzumab) - Dylight® 488 - 100 µg

Item no.	LEIN-LT211-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Category	Oncology Antibodies By Cell Type Hematology Leukemia Lymphoma Flow Cytometry Immunohistochemistry Primary Antibodies Functional Assays
Type	Antibody Monoclonal
Applications	FC, IHC, FA
Clone	Campath-1H
Specific against	Human (Homo sapiens), Monkey (Cynomolgus, Simian), Rhesus macaque
Host	Human
NCBI	1043
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	FA, FC, IHC FF, IHC FFPE
Manufacturer - Category	Recombinant Antibodies>Biosimilar Recombinant Antibodies
Manufacturer - Targets	CD52
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	Clone Campath-1H is a monoclonal antibody that specifically binds to CD52, a protein present on the surface of mature lymphocytes. However, this protein is not present on the stem cells that generated these lymphocytes. Alemtuzumab is targets and destroys mature lymphocytes containing CD-52, and is used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. Anti-Human CD52 (Alemtuzumab) utilizes the same variable regions from the therapeutic antibody Alemtuzumab making it ideal for research projects.
Background	Clone Campath-1H is a monoclonal antibody that specifically binds to CD52, a protein present on the surface of mature lymphocytes. However, this protein is not present on the stem cells that generated these lymphocytes. Alemtuzumab is targets and destroys mature lymphocytes containing CD-52, and is used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. Anti-Human CD52 (Alemtuzumab) utilizes the same variable regions from the therapeutic antibody Alemtuzumab making it ideal for research projects.
Additional Reported Applications For Relevant Conjugates	CyTOF® WB
Other Applications Reported In Literature	IHC FFPE (Formalin-fixed paraffin-embedded tissue) IHC FF (Fresh Frozen) FA
PubMed	CD52
Excitation Laser	Blue Laser (493 nm)
Manufacturer - Research Area	Biosimilars
Manufacturer - Expression host	HEK-293
Manufacturer - Specificity	This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Alemtuzumab. Clone Campath-1H recognizes human CD52. This product is for research use only.
FC Effector Activity	Active
RRID	AB_2893946
Concentration	0.2 mg/ml
Formulation	This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	CD52 is primarily expressed on the surface of mature lymphocytes. Additionally, CD52 is present on most lymphoid derived malignancies. However, variable expression on Myeloma cells should be noted.
Immunogen	Human lymphocytes.
Regulatory Status	Research Use Only (RUO). Non-Therapeutic.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	HE5; CDW52; EDDM5 CDW52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; YTH66.9HL; Alemtuzumab; Biosimilar

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-LT211-100ug-safety-datasheet.pdf