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Anti-Human sRANK - Biotin - 50 µg

Anti-Human sRANK - Biotin - 50 µg

Item no.	LEIN-R1137-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Higashio, K. et al. (1998) Biochem Biophys Res Commun. 253: 395 2. Baron, R. et al. (2006) J clin Invest. 116: 1525 3. Murali, R. et al. (2004) J Biol Chem. 279: 8269 4. Looney, RJ. et al. (2004) J Musculoskelet Neuronal Interact 4: 276
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Det, WB
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	sRANK
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	RANK (Receptor Activator of Nuclear Factor κ B) is a member of the tumor necrosis factor receptor (TNFR) family, which is involved in the regulation of dendritic cell function.1 RANK is expressed on osteoclasts and their precursors, hematopoietic precursors, dendritic cells, and mammary epithelial precursors2 and is known as a regulator of development and activation of osteoclasts in bone remodeling.3 Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arthritis and aseptic loosening of orthopaedic implants.4
Background	RANK (Receptor Activator of Nuclear Factor κ B) is a member of the tumor necrosis factor receptor (TNFR) family, which is involved in the regulation of dendritic cell function.¹ RANK is expressed on osteoclasts and their precursors, hematopoietic precursors, dendritic cells, and mammary epithelial precursors² and is known as a regulator of development and activation of osteoclasts in bone remodeling.³ Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arthritis and aseptic loosening of orthopaedic implants.⁴
PubMed	sRANK
Manufacturer - Specificity	Goat Anti-Human Soluble Receptor Activator of NFkB (sRANK) recognizes Human sRANK. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831664
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human sRANK (Accession # Q9Y6Q6)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, sRANK, TNFRSF11A, CD265, ODFR, OFE, RANK, TRANCER, sRANK, Human, Anti-Human sRANK-Biotin, CD265 antigen, CD265, FEO, loss of heterozygosity, 18, chromosomal region 1, ODFR, ODFROSTS, OFE, OPTB7, Osteoclast differentiation factor receptor, PDB2, RANK, RANKLOH18CR1, Receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, TNFRSF11A, TRANCE R, TRANCER, tumor necrosis factor receptor superfamily member 11A, tumor necrosis factor receptor superfamily, member 11a, activator of NFKB, tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-R1137-50ug-safety-datasheet.pdf