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Anti-Human TCR Vα24-Jα18 (iNKT cell)- FITC - 100 µg

Anti-Human TCR Vα24-Jα18 (iNKT cell)- FITC - 100 µg

Item no.	LEIN-T1709-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Category	Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	6B11
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Van Kaer L., et al. (2004) Nat Rev Immunol. 4(3):231-7 2. Teyton L., et al. (2006) Annu Rev Immunol. 25:297–336 3. Kronenberg M. (2004) Annu Rev Immunol. 23:877–900 4. Van Kaer L & Wu L. (2018) Front Immunol. 9:519
NCBI	28659
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Quality Tested by Leinco FC The suggested concentration for this TCR Vα24-Jα18 antibody for staining cells in flow cytometry is ≤ 5.0 μg per 10⁶ cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Manufacturer - Category	Human MHC\|Monoclonal Antibodies\|Primary Monoclonal Antibodies
Manufacturer - Targets	TCR Vα24-Jα18
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description	TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d1. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNγ, and cytolytic mediators2, 3. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases4.
Background	TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d¹. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNγ, and cytolytic mediators^{2, 3}. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases^{4^.}
PubMed	TCR Vα24-Jα18
Excitation Laser	Blue Laser (490 nm)
Ligand/Receptor	Glycolipid loaded CD1d
Manufacturer - Research Area	Immunology
Manufacturer - Specificity	Clone 6B11 recognizes the invariant CDR3 region of the human Vα24-Jα18 TCR.
RRID	AB_2894352
Concentration	0.2 mg/ml
Formulation	This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	The Vα24-Jα18 TCR is expressed on iNKT cells.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-T1709-100ug-safety-datasheet.pdf