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Anti-Human TWEAK - Biotin - 50 µg

Anti-Human TWEAK - Biotin - 50 µg

Item no.	LEIN-T197-50ug
Manufacturer	Leinco Technologies
Amount	50 ug
Category	Antibodies Western Blot ELISA Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Primary
Applications	WB, ICC, ELISA
Specific against	Goat (Caprine, Capra aegagrus hircus)
Host	Human
Citations	1. Burkly, LC. et al. (2005) Oncogene 24:2613 2. Young, LS. et al. (2003) Biochem Biophys Res Commun. 305:789 3. Kumar, A. et al. (2007) FASEB J. 21:1857 4. Hsueh, AJW. et al. (2006) Molecular Endo. 20:2528
NCBI	8742
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ELISA Det, ICC, WB
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	TWEAK
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family1 that has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities.2 TWEAK induces skeletal muscle atrophy.3 TWEAK functions both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK transcripts are expressed in heart, brain, skeletal muscle, pancreas, immune system, ovary, and placenta.4
Background	TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family¹ that has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities.² TWEAK induces skeletal muscle atrophy.³ TWEAK functions both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK transcripts are expressed in heart, brain, skeletal muscle, pancreas, immune system, ovary, and placenta.⁴
Other Applications Reported In Literature	Immunocytochemistry: Suitable for use at concentration of 5-15 µg/mL
PubMed	TWEAK
Manufacturer - Specificity	Human Anti-Human TNF-Related Weak Inducer of Apoptosis (TWEAK) recognizes Human TWEAK. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831849
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human TWEAK (Accession No.: Q4ACW9)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, TNF-Related Weak Inducer of Apoptosis, TNFSF12, DR3LG, Apo3-Ligand, TWEAK, Human TWEAK, Anti-Human TWEAK, Biotin Conjugate, APO3 ligand, APO3LMGC20669, DR3LGTWEAKAPO3/DR3 ligand, MGC129581, TNF-related weak inducer of apoptosis, TNFSF12, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand superfamily member 12, TWEAK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-T197-50ug-safety-datasheet.pdf