Rabbit antibody to Arg3.1

FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note: associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.

IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Tan J, et al. Neuroscience. 16; 145(2):715-26(2007).

A synthetic peptide from rat Arg3.1 (ARC) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.

http://ca.expasy.org/uniprot/Q7LC44
http://www.uniprot.org/uniprot/Q9WV31
http://ca.expasy.org/uniprot/Q63053

Polyclonal

Lyophilised