Rabbit antibody to Beclin1

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy.
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note: Expressed in dendrites and cell bodies of cerebellar Purkinje cells
TISSUE SPECIFICITY: Ubiquitous

IHC, WB. Use at a dilution of 1 : 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Feng W, et al. J. Mol. Biol. 372 (1), 223-235(2007).

A synthetic peptide from human Beclin1 conjugated to blue carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.

http://ca.expasy.org/uniprot/Q14457
http://ca.expasy.org/uniprot/Q91XJ1
http://ca.expasy.org/uniprot/O88597

Polyclonal

Lyophilised