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Rabbit antibody to phospho T514 & S518 CRMP2

Rabbit antibody to phospho T514 & S518 CRMP2

Item no.	OSC00046W
Manufacturer	Osenses
Amount	100ul
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, N2A3, DPYSL2, CRMP2
Similar products	DPYSL2, CRMP2, Dihydropyrimidinase-related protein 2, Collapsin response mediator protein 2, N2A3, DRP-2
Available
Also known	Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, N2A3, DPYSL2, CRMP2
Target	FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. SUBUNIT: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous.
Spcs X-react.	Human, Mouse, rat. Other species not yet tested.
Applications info	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. This antibody recognises mainly phospho T514 & S518 of CRMP-2 (but also it is quite likely to recognise the unphosphorylated form).
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Shipping	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Goshima Y, et al. Nature 376:509-514(1995). 2. Beausoleil S.A, et al. Nat. Biotechnol. 24:1285-1292(2006).
Limitation	For research use only
Immunogen	A synthetic peptide from the phosphorylated sites of human T514 & S518 of CRMP2 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, mouse and chicken.
Conjugate	Unconjugated antibody
Accession	http://ca.expasy.org/uniprot/Q16555 http://ca.expasy.org/uniprot/P47942 http://ca.expasy.org/uniprot/O08553 http://ca.expasy.org/uniprot/Q90635
Purity	Whole serum
Clonality	Polyclonal
Specificity	Specific for CRMP2.
Format	Lyophilised
Reconstitution	Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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