Rabbit antibody to SLC1A3

FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6). EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Shashidharan P, et al. Biochim. Biophys. Acta 1216:161-164(1993)

A synthetic peptide from extracellular domain of human EAAT1 conjugated to blue carrier protein was used as the antigen. The antigen shares 95% identity with rat and mouse sequence.

http://www.uniprot.org/uniprot/P43003
http://www.uniprot.org/uniprot/P24942
http://www.uniprot.org/uniprot/P56564

Polyclonal

Lyophilised