Rabbit antibody to GABRA1 (390-450)

Involvement in disease: Note=A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv3(q25; q29). The inversion produces a disruption of the protein.
Subcellular location: Membrane; Multi-pass membrane protein. Lysosome
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen.

IHC, WB. A dilution of 1 : 2000 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Schofield P.R, et al. FEBS Lett. 244:361-364(1989)

A synthetic peptide from aa region 390-450 of human GABRA1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://www.uniprot.org/uniprot/P14867
http://www.uniprot.org/uniprot/P62812
http://www.uniprot.org/uniprot/P62813

Polyclonal

Lyophilised