Rabbit antibody to HOMER3

FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release.
SUBUNIT: Encodes coiled-coil structures that mediate homo- and heteromultimerization.
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells.
It may interact with group I metabotropic glutamate receptors and regulate their coupling to membrane ion channels.

IHC, WB. A dilution of 1 : 2000 is recommended fro WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user.

12 months after reconstitution

1. Kammermeier, P. J, et al. J. Neurosci. 20 (19), 7238-7245(2000).

A synthetic peptide from the internal region of rat HOMER3 conjugated to blue carrier protein was used as the antigen.

http://ca.expasy.org/uniprot/Q9Z2X5
http://www.uniprot.org/uniprot/Q99JP6

Polyclonal

Lyophilised