Rabbit antibody to HSP70

FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.

Cellular localization: Cytoplasm. Melanosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue specificity: Ubiquitous

IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Cell Struct. Funct. 35:107-116 (2010)

A synthetic peptide from human HSP71 conjugated to blue carrier protein was used as the antigen.

https://www.uniprot.org/uniprot/P11142
https://www.uniprot.org/uniprot/P63018
https://www.uniprot.org/uniprot/P63017

Polyclonal

Lyophilised