Rabbit antibody to KCNQ3 (60-120)

Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
Tissue specificity: Predominantly expressed in brain. Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.
Subcellular location: Membrane; Multi-pass membrane protein.

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 200 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Schroeder B.C, et al. Nature 396:687-690(1998)
2. Wickenden A.D, et al. Br. J. Pharmacol. 132:381-384(2001)

A synthetic peptide from aa region 60-120 of mouse KCNQ3 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.

http://www.uniprot.org/uniprot/O43525
http://www.uniprot.org/uniprot/Q8K3F6
http://www.uniprot.org/uniprot/O88944

Polyclonal

Lyophilised