Rabbit antibody to Lingo1

Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Subcellular location: Cell membrane; Single-pass type I membrane protein
Tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.

IHC, WB. A dilution of 1 : 3000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Carim-Todd L, et al. Eur. J. Neurosci. 18:3167-3182(2003)
2. Mosyak L, et al. J. Biol. Chem. 281:36378-36390(2006)

A synthetic peptide from c-terminal region of human Lingo1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many other species.

http://www.uniprot.org/uniprot/Q96FE5
http://www.uniprot.org/uniprot/Q562A6
http://www.uniprot.org/uniprot/Q9D1T0

Polyclonal

Lyophilised