Rabbit antibody to Pallidin (50-100)

FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system; Peripheral membrane protein
Note: It can exist as a soluble protein as well as a peripheral membrane protein.
Tissue specificity: Widely expressed.

IHC, WB. A dilution of 1 : 100 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

12 months after reconstitution

1. Huang L., et al. J. Nat. Genet. 23:329-332(1999)

A synthetic peptide from human Pallidin conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with rat and mouse sequences.

http://www.uniprot.org/uniprot/Q9UL45
http://www.uniprot.org/uniprot/Q4V8A6
http://www.uniprot.org/uniprot/Q5U455

Polyclonal

Lyophilised