Comparison

Rabbit antibody to TRPV4

Item no. OSR00062W
Manufacturer Osenses
Amount 100ul
Category
Type Antibody Polyclonal
Applications WB, IHC
Specific against Rat (Rattus norvegicus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-related, smotically-activated channel, VR-OAC, Vroac, Otrpc4
Similar products Transient receptor potential cation channel subfamily V member 4, OTRPC4, VR-OAC, osm-9-like TRP channel 4, TrpV4, Vroac, Vanilloid receptor-related, smotically-activated channel, Otrpc4
Available
Also known
Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-related, smotically-activated channel, VR-OAC, Vroac, Otrpc4
Target
TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure.
FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.
Spcs X-react.
Rat. Other species not yet tested.
Applications info
IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Liedtke W.B, et al. Cell 103:525-535(2000).
Limitation
For research use only
Immunogen
A synthetic peptide from aa region 100-150 of rat conjugated to blue carrier protein was used as the antigen.
Conjugate
Unconjugated antibody
Accession
http://ca.expasy.org/uniprot/Q9ERZ8
Purity
Whole serum
Clonality
Polyclonal
Specificity
Specific for TRPV4.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100ul
Available: In stock
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