Rabbit antibody to MRGPRA (250-300)

FUNCTION: Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.

IHC, WB. A dilution of 1 : 4000 for WB on rat lysates is recommended and for mouse tissue lysates 1 : 2000 i; 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Bender E, et al. Proc. Natl. Acad. Sci. U.S.A. 99:8573-8578(2002).

A synthetic peptide from aa region 250-300 of rat MRGPRA conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q7TN49
http://www.uniprot.org/uniprot/Q91WW2

Polyclonal

Lyophilised