Rabbit antibody to SLC22A8

FUNCTION: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2, 4-dichloro-phenoxyacetate (2, 4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein Potential. Note: Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC)
TISSUE SPECIFICITY: Highly expressed in kidney. Expressed in developing bone. Weakly expressed in brain and eye.

IHC, WB. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Race J.E, et al. Biochem. Biophys. Res. Commun. 255:508-514(1999)

A synthetic peptide from c-terminal region of human SLC22A8 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q8TCC7
http://www.uniprot.org/uniprot/L7N0W9

Polyclonal

Lyophilised