Rabbit antibody to SLC4A1

Function: Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4). EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
Defects in SLC4A1 are the cause of spherocytosis type 4 (SPH4); also known as hereditary spherocytosis type 4 (HS4). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal.
Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (AD-dRTA). This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis.
Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (AR-dRTA).
Tissue specificity: Erythrocytes.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein

IHC, WB. A dilution of 1: 30000 to 1:100000 is recommended for WB and 1:2000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Lux S.E, et al. Proc. Natl. Acad. Sci. U.S.A. 86:9089-9093(1989)

A synthetic peptide from human Band 3 anion transport protein (SLC4A1, CD233) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://www.uniprot.org/uniprot/P02730
http://www.uniprot.org/uniprot/P04919
http://www.uniprot.org/uniprot/P23562

Polyclonal

Lyophilised